Tag: books

California Is a Nobel Powerhouse

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You can keep your Oscars, Emmys, Grammys, and Tonys. Take your Pulitzers, Bookers, and Peabodys, too. Even the Pritzker and the Fields Medal don’t quite measure up. For me, nothing competes with the Nobel Prize as a symbol that someone has truly changed the world.

I’m not a scientist, but my mind lives in that space. Science, more than anything else, runs the world and reshapes it. This newsletter was born out of my fascination with how things work and the quiet mechanics behind the visible world and my love for all that California has to offer in the way of innovation and natural beauty. I love standing in front of something familiar and asking: why? how? what exactly is going on here? And nothing satisfies that intense curiosity more than science.

That said, I’ve never loved the word science. It feels cold and sometimes intimidating, as if it applies to people in lab coats and not to everyone else. I kinda wish there were a better word for that spirit of discovery that lives in all of us. Maybe it’s wonder. Maybe curiosity. I dunno. “Science” turns people off sometimes, unfortunately.

Whatever you call it, the Nobel Prize represents the highest acknowledgment of that pursuit. It is the world’s way of saying: this mattered. This changed something. And there are few places (if any) on Earth that can rival California when it comes to the number of people who have earned that honor.

This year, 2025, was no different. Three of the Nobel Prizes announced this week carried California fingerprints, adding to a tradition that stretches back more than a century.

The Nobel Prize in Physiology or Medicine came first. It went to Mary Brunkow, Shimon Sakaguchi, and Fred Ramsdell, the last of whom studied at UCLA and UC San Diego. (In epic California fashion, Ramsdell, who studied at UCLA and UC San Diego, didn’t even learn he’d become a Nobel laureate until after returning from a trip deep into the Wyoming wilderness, where he’d been out of contact with the outside world. What’s more Californian than that?) Their research on regulatory T cells explained how the immune system knows when to attack and when to stand down. Ramsdell’s discovery of a key gene that controls these cells has transformed how scientists think about autoimmune disease and organ transplantation.

Next came the Nobel Prize in Physics, awarded to John Clarke of UC Berkeley, Michel H. Devoret of UC Santa Barbara and Yale, and John M. Martinis of UC Santa Barbara (big shout out to UCSB!). Their award honored pioneering work that revealed how the strange laws of quantum mechanics can be seen in circuits large enough to hold in your hand. Beginning in Clarke’s Berkeley lab in the 1980s, the trio built superconducting loops that behaved like subatomic particles, “tunneling” and flipping between quantum energy states. Those experiments helped create the foundation for today’s quantum computers.

The Chemistry Prize followed a day later, shared by Susumu Kitagawa, Richard Robson, and Omar M. Yaghi of UC Berkeley for discoveries in metal–organic frameworks, or MOFs. These are crystalline materials so porous that a single gram can hold an entire roomful of gas (mind blown). MOFs are now used to capture carbon dioxide, filter water, and even pull drinking water from desert air. Yaghi’s Berkeley lab coined the term “reticular chemistry” to describe this new molecular architecture. His work has become one of California’s most important contributions to the climate sciences.

California Institute of Technology (Photo: Erik Olsen)

Those three announcements in as many days lit up California’s scientific community, has garnered many headlines and carried on a tradition that has made the state one of the world’s most reliable engines of Nobel-level discovery.

The University of California system now counts 74 Nobel Prizes among its faculty and researchers. 23 in physics and 16 in chemistry. Berkeley leads the list, with 26 laureates, followed by UC San Diego, UCLA, UC Santa Barbara, and UC San Francisco. Even smaller campuses, such as UC Riverside, have ties to winners like Barry Barish, who shared the 2017 Nobel in Physics for detecting gravitational waves.

Linus Pauling with an inset of his Nobel Prize in 1955 (Wikipedia – public domain)

Caltech, which I have written about extensively and is quite close to my own home, counts 47 Nobel laureates (faculty, alumni, or postdocs). Its history is the stuff of legend. In 1923, Robert Millikan won for measuring the charge of the electron. In 1954, Linus Pauling received the Chemistry Prize for explaining the nature of the chemical bond. He later won the Peace Prize for his anti-nuclear activism, making him the only person to win two unshared Nobels.

Stanford University sits not far behind, with 36 Nobel winners in its history and about 20 currently active in its community. From the development of transistors and lasers to modern work in medicine and economics, Stanford’s laureates have changed the modern world in ways that is impossible to quantify, but profound in their impact.

These numbers tell a clear story: since the mid-twentieth century, about one in every four Nobel Prizes in the sciences awarded to Americans has gone to researchers based at California institutions, an extraordinary concentration of curiosity, intellect, and ambition within a single state.

University of California Santa Barbara (Photo: Erik Olsen)

California’s Nobel dominance began early. In the 1930s, UC Berkeley’s Ernest Lawrence invented the cyclotron, a device that would transform physics and eventually medicine. Caltech, meanwhile, became a magnet for the world’s brightest physicists and chemists.

Over the decades, California’s universities turned their focus to molecular biology, biochemistry, and genetics. In the 1980s, the state’s physicists and engineers drove advances in lasers, semiconductors, and now, quantum circuits. And as biotechnology rose, San Diego and the Bay Area became ground zero for breakthroughs in medicine and life sciences. One of the great moments in genetics took place in Asilomar on the coast. 

Nobel Museum in Stockholm, Sweden (Photo: Erik Olsen)

This is all about more than geography and climate (although those are a big sell, for sure). California’s research institutions kick ass because they operate as ecosystems rather than islands. Berkeley physicists collaborate with engineers at Stanford. Caltech chemists trade ideas with biotech firms in San Diego. Graduate students drift between labs, startups, and national research centers like Lawrence Livermore and JPL. The boundaries between university and industry blur, with campuses like Stanford turning breakthrough discoveries into thriving commercial ventures (look how many of our big tech brains came out of Stanford). In California, research doesn’t end in the lab, it often turns into companies, technologies, and treatments that generate both knowledge and enormous economic value. Just look at AI today. 

Check out our Etsy store for cool California wildlife swag.

I think the secret is cultural. Over the years, I’ve lived on the East coast for almost two decades, and abroad for several as well, and nothing compares to the California vibe. California has never been afraid of big risks. Its scientists are encouraged to chase questions that might take decades to answer (see our recent story on just this idea). There’s an openness to uncertainty here that works well in the natural sciences, but can also be found in Hollywood, Silicon Valley and, of course, space exploration. 

When next year’s round of early morning calls comes from Stockholm, it is a good bet that someone in California will pick up. Maybe a physicist in Pasadena, a chemist in Berkeley, or a physician in La Jolla. Maybe they’ll pick up the phone in bed, maybe a text from a spouse while camping, or on a morning jog. That’s when a Swedish-accented voice tells them that the world has just caught up to what they’ve been quietly building for years.

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The Unsung California Labs That Powered the Digital Revolution

Researchers at Lawrence Livermore National Laboratory working with the Big Aperture Thulium (BAT) laser system, part of the laser and plasma research that laid the groundwork for generating the extreme ultraviolet light at the heart of today’s most advanced chipmaking machines. (Photo: Jason Laurea/LLNL)
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When I started this Website, my hope was to share California’s astonishing range of landscapes, laboratories, and ideas. This state is overflowing with scientific discovery and natural marvels, and I want readers to understand, and enjoy, how unusually fertile this state is for discovery. If you’re not curious about the world, then this Website is definitely not for you. If you are, then I hope you get something out of it when you step outside and look around. 

I spend a lot of time in the California mountains and at sea, and I am endlessly amazed by the natural world at our doorstep. I am also fascinated by California’s industrial past, the way mining, oil, and agriculture built its wealth, and how it later became a cradle for the technologies and industries now driving human society forward. Of course, some people see technologies like gene editing and AI as existential risks. I’m an optimist. I see tools that, while potentially dangerous, used wisely, expand what is possible.

An aerial view of Lawrence Livermore National Laboratory in 1960, when the Cold War spurred rapid expansion of America’s nuclear and scientific research campus east of San Francisco Bay. (Photo: LLNL Public Domain)

Today’s story turns toward technology, and one breakthrough in particular that has reshaped the modern world. It is not just in the phone in your pocket, but in the computers that train artificial intelligence, in advanced manufacturing, and in the systems that keep the entire digital economy running. The technology is extreme ultraviolet lithography (EUV). And one of the most important points I want to leave you with is that the origins of EUV are not found in Silicon Valley startups or corporate boardrooms but in California’s national laboratories, where government-funded science made the impossible possible.

This article is not a political argument, though it comes at a time when government funding is often questioned or dismissed. My purpose is to underscore how much California’s national labs have accomplished and to affirm their value.

This story begins in the late 1980s and 1990s, when it became clear that if Moore’s Law was going to hold, chipmakers would need shorter and shorter wavelengths of light to keep shrinking transistors. Extreme ultraviolet light, or EUV, sits way beyond the visible spectrum, at a wavelength far shorter than ordinary ultraviolet lamps. That short wavelength makes it possible to draw patterns on silicon at the tiniest scales…and I mean REALLY tiny.

Ernest Orlando Lawrence at the controls of the 37-inch cyclotron in 1938. A Nobel Prize–winning physicist and co-founder of Lawrence Livermore National Laboratory, Lawrence’s legacy in nuclear science and high-energy research paved the way for the laboratory’s later breakthroughs in lasers and plasma physics — work that ultimately fed into the extreme ultraviolet light sources now powering the world’s most advanced chipmaking machines. (LLNL Public Domain)

At Lawrence Berkeley National Laboratory, researchers with expertise in lasers and plasmas were tasked with figuring out how to generate a powerful, reliable source of extreme ultraviolet light for chipmaking. Their solution was to fire high-energy laser pulses at microscopic droplets of tin, creating a superheated plasma that emits at just the right (tiny) wavelength for etching circuits onto silicon.

The movement of light on mirrors in an ASML EUV lithography machine. More on it below.

Generating the light was only the first step. To turn it into a working lithography system required other national labs to solve equally daunting problems. Scientists at Berkeley’s Center for X Ray Optics developed multilayer mirrors that could reflect the right slice of light with surprising efficiency. A branch of Sandia National Laboratories located in Livermore, California, worked on the pieces that translate light into patterns. So, in all: Livermore built and tested exposure systems, Berkeley measured and perfected optics and materials, and Sandia helped prove that the whole chain could run as a single machine.

Each EUV lithography machine is about the size of a bus, costs more than $150 million, and shipping one requires 40 freight containers, three cargo planes, and 20 trucks. (Photo: ASML)

It matters that this happened in public laboratories. The labs had the patient funding and the unusual mix of skills to attempt something that might not pay off for many years. The Department of Energy supported the facilities and the people. DARPA helped connect the labs with industry partners and kept the effort moving when it was still risky. There was no guarantee that the plasma would be bright enough, that the mirrors would reflect cleanly, or that the resists (the light-sensitive materials coated onto silicon wafers) would behave. The national labs could take that on because they are designed to tackle long horizon problems that industry would otherwise avoid.

Only later did private industry scale the laboratory breakthroughs into the giant tools that now anchor modern chip factories. The Dutch company ASML became the central player, building the scanners that move wafers with incredible precision under the fragile EUV light. Those systems are now capable of etching transistor features as small as 5 nanometers…5 billionths of a meter. You really can’t even use the “smaller than a human hair” comparison here since human hair variation is so large at this scale as to render that comparison kind of useless. However, many people still do.

The ASML machines are marvels of tech and engineering. Truly amazing feats human design. And they integrate subsystems from all over the world: Zeiss in Germany manufactures the mirrors, polished to near-atomic perfection, while San Diego’s Cymer (now part of ASML) supplies the laser-driven plasma light sources. The technology is so complex that a single scanner involves hundreds of thousands of components and takes months to assemble.

ASML’s EXE:5000 High-NA EUV lithography machine — a room-sized tool that etches the tiniest features on the world’s most advanced computer chips. (ASML)

It was TSMC and Samsung that then poured billions of dollars into making these tools reliable at scale, building the factories that now turn EUV light into the chips powering AI and smartphones and countless other devices. Trillions of dollars are at stake. Some say the fate of humanity lies in balance should Artificial General Intelligence eventually emerge (again, I don’t say that, but some do). All of this grew from the ingenuity and perseverance, along with the public funding, that sustained these California labs.

It’s disappointing that many of the companies profiting most from these technological breakthroughs are not based in the United States, even though the core science was proven here in California. That is fodder for a much longer essay, and perhaps even for a broader conversation about national industrial policy, something the CHIPS Act is only beginning to deal with.

However, if you look closely at the architecture of those monster machines, you can still see the fingerprints of the California work. A tin plasma for the light. Vacuum chambers that keep the beam alive. Reflective optics that never existed at this level before EUV research made them possible.

A photorealistic rendering of an advanced microprocessor, etched in silicon with extreme ultraviolet light — the kind of breakthrough technology pioneered in U.S. national labs, but now fabricated almost entirely in Taiwan, where the future of digital society is being made.

We often celebrate garages, founders, and the venture playbook. Those are real parts of the California story. This is a different part, just as important. The laboratories in Livermore, Berkeley, and Sandia are public assets. They exist because voters and policymakers chose to fund places where hard problems can be worked on for as long as it takes. The payoff can feel distant at first, then suddenly it is in your pocket. Like EUV. Years of quiet experiments on lasers, mirrors, and materials became the hidden machinery of the digital age.

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